Decidual-Like NK Cell Polarization: From Cancer Killing to Cancer Nurturing
نویسندگان
چکیده
Abstract Summary: Natural killer (NK) cells accumulate at the fetal–maternal interface and represent 70% of immune in decidua (dNK) first-trimester pregnancy; they are immune-tolerant toward semiallogenic fetus “nurturing” nonkilling NK cells. A subset patients with cancer have features common dNK, which include expressing CD56, CD9, CD49a, CXCR3, being poorly cytotoxic proangiogenic, mimicking decidual nurturing role. In oncologic patient, several factors can “decidualize” cells, turning them into immune-suppressant, growth-promoting proangiogenic Here, we suggest ways to sharpen their blunted blades intercept curb cancer-nurturing attitudes restore capabilities.
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2021
ISSN: ['2159-8290', '2159-8274']
DOI: https://doi.org/10.1158/2159-8290.cd-20-0796